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switching
Antisense OligoNucleotides for switching target transcript to an alternate splice-isoform
- Modulation of specific splice event
- Transcript-specific switching
- Phenotype-based validation of targets
- Pathway-centric and gene-family options
- Covers major types of splicing patterns
Example Paper
PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the
Pro-tumorigenic Effects of Senescent Cells
Georgilis et al. 2018. Cancer Cell
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knock-down
Antisense OligoNucleotides for target transcript knockdown
- Induction of RNase H degradation
- Transcript-specific knockdown
- Phenotype-based validation of targets
- Pathway-centric and gene-family options
- Overcomes off-target issues (e.g. siRNA)
Example Paper
Gapmer, siRNA, SSO and their effects on transcript knockdown efficiency
Bin Muzakar et al. 2021. Manuscript in preparation
Transcript
knock-down
Antisense OligoNucleotides for target transcript knockdown
- Induction of Nonsense-Mediated Decay (NMD)
- Transcript-specific knockdown
- Phenotype-based validation of targets
- Pathway-centric and gene-family options
- Overcomes off-target issues (e.g. siRNA)
Example Paper
MYC regulates the core pre-mRNA splicing machinery as an essential step in lymphomagenesis
Koh et al. 2015. Nature